Target/Analyte:
Doxorubicin

Short Name Doxorubicin
Description Doxorubicin, sold under the trade names Adriamycin among others, is a chemotherapy medication used to treat cancer. This includes breast cancer, bladder cancer, Kaposi's sarcoma, lymphoma, and acute lymphocytic leukemia. It is often used together with other chemotherapy agents. Doxorubicin is given by injection into a vein.

Method/Kits with this Target/Analyte
Method/Kit Description
LC-MS/MS Determination of analyte concentration by LC-MS/MS
RapidFire-MS The RapidFire 365 High-Throughput Mass Spectrometry System significantly increases the throughput of LC/MS analyses by replacing HPLC with automated solid phase extraction (SPE). An integrated robot manages reusable SPE cartridges, which are available in a variety of chemistries to optimize selectivity. The RapidFire 365 is a high speed autosampler that can be integrated with Agilent’s Triple Quadrupole, Time-of-Flight, and Quadrupole Time-of-Flight mass spectrometers. RapidFire enables automated high-capacity sample analysis in a wide range of applications, even in biological matrices. The technology provides a more successful approach to HTS of challenging drug targets and a 10x faster throughput for MS-based analyses like HT-ADME discovery assays. This end to end solution delivers shorter time to results, reduced operational costs and automated high-capacity sample processing.
Single-Use RED Plate with Inserts (Thermo Scientific: 2034.6) and ICP-MS Single-Use RED Plate with Inserts (Thermo Scientific: 2034.6) followed by mass spectrometry for quantification of compound and determination of: % Free = (Concentration buffer chamber/Concentration plasma chamber) × 100% and % Bound = 100% - % Free.

Studies Utilizing this Target/Analyte
Study Start Date Study Types Description
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