Target/Analyte:
Cellular Morphology Score

Short Name Cell Morphology Scor
Description A score of 0 represents no hepatotoxicity detected, which is defined by 95-100% healthy hepatocyte morphology, hexagonal shape containing binucleated cells, clear cell cytoplasm, distinctive cell junctions and less than 5% dead cells. A score of 1 represents at least 85% healthy hepatocyte morphology, a hexagonal shape containing binucleated cells, clear cell cytoplasm, distinctive cell junctions but < 15% are dead cells. A score of 2 represents mild hepatotoxicity with > 70% monolayer of hepatocytes visible, evidence that cells have begun to lose their distinct cell junctions, many cells contain a granulated cytoplasm but < 30% are dead cells. A score of 3 represents moderate hepatotoxicity with severe granulation of cytoplasm and most of the cells have lost their junctions. Approximately 50% of the cells are considered dead. A score of 4 represents severe hepatotoxicity with agglomeration of cell debris and > 50% of the cells are considered dead.

Method/Kits with this Target/Analyte
Method/Kit Description
Microscopy - Brightfield Microscopy using brightfield sample illumination

Studies Utilizing this Target/Analyte
Study Start Date Study Types Description
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