Target/Analyte:
Diclofenac

Short Name Diclofenac
Description Diclofenac

Method/Kits with this Target/Analyte
Method/Kit Description
HPLC-MS As the name suggest the instrumentation comprises a high performance liquid chromatograph (HPLC) attached, via a suitable interface, to a mass spectrometer (MS). The primary advantage HPLC/MS has over GC/MS is that it is capable of analysing a much wider range of components.
LC-MS/MS Determination of analyte concentration by LC-MS/MS
RapidFire-MS The RapidFire 365 High-Throughput Mass Spectrometry System significantly increases the throughput of LC/MS analyses by replacing HPLC with automated solid phase extraction (SPE). An integrated robot manages reusable SPE cartridges, which are available in a variety of chemistries to optimize selectivity. The RapidFire 365 is a high speed autosampler that can be integrated with Agilent’s Triple Quadrupole, Time-of-Flight, and Quadrupole Time-of-Flight mass spectrometers. RapidFire enables automated high-capacity sample analysis in a wide range of applications, even in biological matrices. The technology provides a more successful approach to HTS of challenging drug targets and a 10x faster throughput for MS-based analyses like HT-ADME discovery assays. This end to end solution delivers shorter time to results, reduced operational costs and automated high-capacity sample processing.
Single-Use RED Plate with Inserts (Thermo Scientific: 2034.6) and LC-MS Single-Use RED Plate with Inserts (Thermo Scientific: 2034.6) followed by mass spectrometry for quantification of compound and determination of: % Free = (Concentration buffer chamber/Concentration plasma chamber) × 100% and % Bound = 100% - % Free.

Studies Utilizing this Target/Analyte
Study Start Date Study Types Description
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