Target/Analyte:
Osteonectin

Short Name ONN
Description Osteonectin (ON) also known as secreted protein acidic and rich in cysteine (SPARC) or basement-membrane protein 40 (BM-40) is a protein that in humans is encoded by the SPARC gene.

Osteonectin is a glycoprotein in the bone that binds calcium. It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for collagen in addition to bone mineral calcium. A correlation between osteonectin over-expression and ampullary cancers and chronic pancreatitis has been found.

Method/Kits with this Target/Analyte
Method/Kit Description
Human Bone Panel II Kit (MSD: K15147C) The Human Bone Marker Panel II Kit provides assay-specific components for the quantitative determination of both natural and recombinant human osteocalcin (OCL), osteonectin (ONN), and osteopontin (OPN) in serum and plasma.

Studies Utilizing this Target/Analyte
Study Start Date Study Types Description
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