Method/Kit:
Human Bone Panel II Kit (MSD: K15147C)

Supplier MSD
Measurement Type Fluorescence Intensity
Description The Human Bone Marker Panel II Kit provides assay-specific components for the quantitative determination of both natural and recombinant human osteocalcin (OCL), osteonectin (ONN), and osteopontin (OPN) in serum and plasma.


Target/Analytes with this Method/Kit
Target/Analyte Short Name Description
Osteocalcin OCL Osteocalcin, also known as bone gamma-carboxyglutamic acid-containing protein (BGLAP), is a noncollagenous protein hormone found in bone and dentin. Because it has gla domains, its synthesis is vitamin K dependent. In humans, the osteocalcin is encoded by the BGLAP gene. Its receptor is GPRC6A.
Osteonectin ONN Osteonectin (ON) also known as secreted protein acidic and rich in cysteine (SPARC) or basement-membrane protein 40 (BM-40) is a protein that in humans is encoded by the SPARC gene. Osteonectin is a glycoprotein in the bone that binds calcium. It is secreted by osteoblasts during bone formation, initiating mineralization and promoting mineral crystal formation. Osteonectin also shows affinity for collagen in addition to bone mineral calcium. A correlation between osteonectin over-expression and ampullary cancers and chronic pancreatitis has been found.
Osteopontin OPN Osteopontin (OPN) is a 35kDa secreted adhesive glycophosphoprotein that belongs to the small integrin-binding ligand N-linked glycoprotein family (SIBLING) and it is expressed mainly in bone, teeth, kidney, epithelial lining tissues, activated T cells and macrophages and found in plasma and breast milk. It is processed by matrix metalloproteases 3 and 4 as well as thrombin, which generate two functional fragments: an N terminal (RGD) fragment that binds to integrin receptors and a C terminal fragment (containing heparin binding sites) that interacts with CD44. Osteopontin can be present as a cytokine-like soluble protein or an immobilized extracellular matrix protein. Osteopontin is important in multiple physiologic and pathologic processes including survival, adhesion, migration, angiogenesis, apoptosis, inflammation, macrophage migration, B cell proliferation, Ig production, wound healing and tumor metastasis.

Studies Utilizing this Method/Kit
Study Start Date Study Types Description
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