Method/Kit:
Microscopy - Brightfield

Measurement Type Imaging
Description Microscopy using brightfield sample illumination

Target/Analytes with this Method/Kit
Target/Analyte Short Name Description
Cellular Morphology Score Cell Morphology Scor A score of 0 represents no hepatotoxicity detected, which is defined by 95-100% healthy hepatocyte morphology, hexagonal shape containing binucleated cells, clear cell cytoplasm, distinctive cell junctions and less than 5% dead cells. A score of 1 represents at least 85% healthy hepatocyte morphology, a hexagonal shape containing binucleated cells, clear cell cytoplasm, distinctive cell junctions but < 15% are dead cells. A score of 2 represents mild hepatotoxicity with > 70% monolayer of hepatocytes visible, evidence that cells have begun to lose their distinct cell junctions, many cells contain a granulated cytoplasm but < 30% are dead cells. A score of 3 represents moderate hepatotoxicity with severe granulation of cytoplasm and most of the cells have lost their junctions. Approximately 50% of the cells are considered dead. A score of 4 represents severe hepatotoxicity with agglomeration of cell debris and > 50% of the cells are considered dead.
Image IMG Image for later analysis of intensity, morphology, distribution, location, etc.
Cell Morphology Cell Morphology Imaging, typically with transmitted light, to see the cell morphology.
Image IMG Image for later analysis of intensity, morphology, distribution, location, etc.
Live Cells LIVE Number or percent of live cells

Studies Utilizing this Method/Kit
Study Start Date Study Types Description
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