Method/Kit:
MILLIPLEX MAP Human Kidney Injury Magnetic Bead Panel 1 - Toxicity Multiplex Assay

Supplier EMD Millipore
Measurement Type Fluorescence Intensity
Description The analytes available for this multiplex kit are: Calbindin, Collagen IV, Fatty Acid Binding Protein 1 (FABP1), GSTα, IP-10, Kidney Injury Molecule-1 (KIM-1), Osteoactivin, Renin, TFF-3, TIMP-1.

Target/Analytes with this Method/Kit
Target/Analyte Short Name Description
Calbindin CLBNDN Calbindin is a calcium-binding protein that acts as an endogenous calcium buffer (Li, Decavel, & Hatton, 1995).
Fatty Acid-Binding Protein 1 FABP-1 FABP1 is primarily expressed in the liver where it is involved in the binding, transport and metabolism of long-chain fatty acids (LCFAs), endocannabinoids, phytocannabinoids (and less so for synthetic cannabinoid receptor (CBR) agonists and antagonists) and other hydrophobic molecules. Altered expression of the protein has been linked to metabolic conditions including obesity.
Glutathione S-transferase GST-A Increases in serum and urinary GST-A1 have been found in association with hepatocyte and renal proximal tubular necrosis respectively and have potential for monitoring injury to these tissues
interferon-inducible protein 10 IP-10 CXCL10 is secreted by several cell types in response to IFN-γ. These cell types include monocytes, endothelial cells and fibroblasts
KIM-1 (human) KIM-1 Kidney injury molecule 1 (KIM-1) is a cell surface receptor that is expressed on kidney epithelial cells and by distinct T cell populations and hepatocytes. In acutely injured kidneys, KIM-1 is thought to confer a phagocytic phenotype on kidney epithelial cells that contributes to recovery by removing debris from cells that died during the injury. In patients with CKD, on the other hand, elevated KIM-1 expression has been shown to occur close to inflammatory cells and fibrotic tissue. However, whether KIM-1 actively promotes kidney fibrosis has not been resolved..
Osteoactivin Osteoactivin Osteoactivin works as a positive regulator of osteoblast differentiation during later stages of matrix maturation and mineralization
Renin Renin Renin (etymology and pronunciation), also known as an angiotensinogenase, is an aspartic protease protein and enzyme secreted by the kidneys that participates in the body's renin–angiotensin–aldosterone system (RAAS)—also known as the renin–angiotensin–aldosterone axis—that mediates the volume of extracellular fluid (blood plasma, lymph and interstitial fluid) and arterial vasoconstriction. Thus, it regulates the body's mean arterial blood pressure.
TIMP metallopeptidase inhibitor 1 (TIMP-1) TIMP-1 TIMP metallopeptidase inhibitor 1, also known as TIMP1, a tissue inhibitor of metalloproteinases, is a glycoprotein that is expressed from the several tissues of organisms.
Trefoil factor 3 TFF-3 Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfide bonds. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are diverse, including protection of the mucosa, thickening of the mucus, and increasing epithelial healing rates. This gene is a marker of columnar epithelium and is expressed in a variety of tissues including goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21.
Type IV Collagen Collagen IV Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina.

Studies Utilizing this Method/Kit
Study Start Date Study Types Description
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