Method/Kit:
Human Osteopontin Quantikine ELISA (R&D Systems DOST00)

Supplier R&D Systems
Measurement Type Absorbance
Description Human osteopontin secretion ELISA

Target/Analytes with this Method/Kit
Target/Analyte Short Name Description
Osteopontin OPN Osteopontin (OPN) is a 35kDa secreted adhesive glycophosphoprotein that belongs to the small integrin-binding ligand N-linked glycoprotein family (SIBLING) and it is expressed mainly in bone, teeth, kidney, epithelial lining tissues, activated T cells and macrophages and found in plasma and breast milk. It is processed by matrix metalloproteases 3 and 4 as well as thrombin, which generate two functional fragments: an N terminal (RGD) fragment that binds to integrin receptors and a C terminal fragment (containing heparin binding sites) that interacts with CD44. Osteopontin can be present as a cytokine-like soluble protein or an immobilized extracellular matrix protein. Osteopontin is important in multiple physiologic and pathologic processes including survival, adhesion, migration, angiogenesis, apoptosis, inflammation, macrophage migration, B cell proliferation, Ig production, wound healing and tumor metastasis.

Studies Utilizing this Method/Kit
Study Start Date Study Types Description
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